The Journal of Antibiotics 6-0-demethyl-5-deoxyfusarubin and Its Anhydro Derivative Produced by a Mutant of the Fungus Nectria Haematococca Blocked in Fusarubin Biosynthesis
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A new deoxyfusarubin produced by the fungus Nectria haematococca. Synthesis of the two isomeric deoxyanhydronaphthopyranones from toralactone.
between anhydrofusarubin lactol and ammoniawas shown on an other side to be responsible for the formation of the antibiotic bostrycoidin2). This 2-aza-anthraquinone was accompanied by a 6-0demethyl-5-deoxy derivative in a selected mutant of N. haematococca^. The structural variations observed in the various naphthopyranones result from subsequent methylations or hydroxylations of the original h...
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A new antifungal diketopiperazine named haematocin was isolated from the culture broth of Nectria haematococca Berk. et Br. (880701a-1) causing blight disease on ornamental plants, Phalaenopsis spp. and Doritanopsis spp. Its structure was established by spectroscopic methods. Haematocin inhibited the germ-tube elongation and spore-germination of Pyricularia oryzae at the ED50 values of 30 micro...
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Chickpea (Cicer arietium L.) produces the antimicrobial compounds (phytoalexins) medicarpin and maackiain in response to infection by microorganisms. Nectria haematococca mating population (MP) VI, a fungus pathogenic on chickpea, can metabolize maackiain and medicarpin to less toxic products. These reactions are thought to be detoxification mechanisms in N. haematococca MP VI and required for ...
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We identified a polyketide synthase (PKS) gene, pksN, from a strain of Nectria haematococca by complementing a mutant unable to synthesize a red perithecial pigment. pksN encodes a 2,106-amino-acid polypeptide with conserved motifs characteristic of type I PKS enzymatic domains: beta-ketoacyl synthase, acyltransferase, duplicated acyl carrier proteins, and thioesterase. The pksN product groups ...
متن کامل19F nuclear magnetic resonance analysis of 5-fluorouracil metabolism in wild-type and 5-fluorouracil-resistant Nectria haematococca.
A mutant (furA3) was isolated from the S1 wild-type strain of Nectria haematococca on the basis of its resistance to 5-fluorouracil (5FU). This mutant has greatly reduced activity of uracil phosphoribosyltransferase, a pyrimidine salvage enzyme catalyzing the synthesis of UMP from uracil. The metabolism of 5FU was examined in both strains by using 19F nuclear magnetic resonance spectroscopy. In...
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